Zoe Daily30+

Does it work?

Zoe have a new supplement out. Is it any good? Does it work? And is it science-backed? Let’s dig in.

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The good

It’s a mix of whole ingredients including nuts, seeds, wholegrains, legumes, vegetables and spices.

None of those are going to do you any harm unless you have an allergy. These are very healthy ingredients. And in fact, there’s reasonable evidence that small differences in intake (eg small serving of nuts (30g) a day) can meaningfully improve your health.

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The kind of good

It’s probably a good thing that this supplement contains a mixture of different plants, but there’s nothing special about this particular mix.

Most plants and plant-sourced foods (eg oils) provide a variety of different types of nutrients and non-nutrient compounds which are beneficial.

For example, flaxseed contains the fibres cellulose, hemicellulose, lignin and some soluble fibres. However, by getting a mix of types of fibres, either from this product, or from bread, cereals, fruits, veg, nuts and seeds it will help to ensure you get a bunch of different types.

What about the spices? Despite lots of noise about spices being great for the microbiome, I can’t find (and neither can reputable academics) good evidence for their benefit. There’s one randomised controlled trial which gave a few spices and then reported a few random changes in a few of the thousands of microbes they measured. Read here for why measuring loads of outcomes is poor practice; and here for why most microbiome research is low quality.

Finally, although Zoe cite a bunch of studies showing the effect of the different ingredients on things, the individual studies used doses which are way higher than are in the Daily30+ supplement. For example, the spice study (not that it showed anything conclusive) tested 6g and 12g of spices, and I would guess a serving of Daily30+ itself has a maximum of 1g of spices in total.

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The bad

It’s Zoe, so of course the bad bit is the science.

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I don’t think anyone would argue adding seeds etc onto yoghurts, cereal etc is a good thing. And everyone knows fibre is good for us and good for our microbes.

What “science” is there to do?

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Well, as Zoe correctly state, many people can struggle to get in enough fruit, veg, wholegrains etc. So maybe it would be useful to know to what extent a supplement like this could improve a sub-optimal diet.

I should note here that they do say “Daily30+ isn’t a replacement for a healthy diet”. But 1) they are legally required to say this and 2) the rest of the text (and their adverts) sure do seem to hint that the supplement can make up “these shortfalls”, eg:

The * here is to advise us that the supplement “contains a natural source of copper which contributes to normal energy yielding metabolism”.

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So how about a trial which compares a fruit and veg-poor diet supplemented with Daily30+ against a diet with 5 servings of fruit and veg? On something meaningful like blood pressure?

Or how about - if you’re going to charge an extortionate amount (£90/kilo) for the supplement under the guise that it’s “science-backed” - you demonstrate that it’s better than just a bog-standard bag of flaxseeds (£8-12/kilo)?

But this is Zoe.

So instead what we get is a trial comparing a bag of [high-fibre] nuts and seeds to croutons (no fibre) and a probiotic containing one strain of bacteria (no fibre) and then measuring “changes in the microbiome” as an outcome. Lol.

Again, I wrote a piece “Why I laugh at most microbiome trials” on why the microbiome is usually a sketchy outcome but briefly: since 1) the microbiome has zillions of species, which 2) can be grouped in zillions of ways, and 3) it changes constantly, if you don’t define specifically what changes you are looking for, you can just look at whatever changes in bacteria you get (or don’t get) and declare it “a win”.

Also: L. rhamnosus (the probiotic used as the second control in this study) might alter the amount of L. rhamnosus in the microbiome but it does surprisingly little to overall microbiome composition. (And again, you can just decide how you define “changes in the microbiome”, “microbiome composition” “relative abundance of microbiome species” etc in whatever way gets your trial that result you want anyway):

From the clinical trial registration where investigators have to say what they’re looking for before they do the study (NCT06231706 on clinicaltrials.gov)l.

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What about the multiple other outcomes measured?

There are no changes in the cardiometabolic stuff that matters (waist circumference, cholesterol, triglycerides).

There are also improvements in gastrointestinal symptoms which isn’t a surprise with getting more fibre.

There are reported improvements in “energy” and “happiness”, but these are very subjective outcomes which are undoubtedly influenced by the fact that the group getting Daily30+ knew they were getting the fancy new supplement and thus probably just felt better as a result.

In summary, they’ve compared 10g fibre per day against no fibre per day, and chosen a primary outcome which improves with fibre and LO AND BEHOLD the supplement “worked”. *

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The really bad

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Even worse than the science itself is PRETENDING THEY’VE DONE SCIENCE.

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Look, I’m not saying this supplement is unhealthy. It’s got a bunch of great stuff in it, but there’s no scientific innovation here. You could exchange nearly every single one** of the ingredients and switch out with another, and it wouldn’t make the slightest bit of difference.

It’s not like they’ve developed a new peptide; or a new bread product with more amylose; or proven that this particular mix is unique.

It’s a bag of seeds.

The use of words “ground-breaking”, “developed by scientists”, “tested in a clinical trial” give the veneer of science. Zoe has well and truly entered grifting territory.

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People sleep on peas (because they’re not expensive or exotic?) but they are just as good for you as any plant-food. I eat them 3 times a week. Don’t feel like you need goji berries and shiitake mushrooms to be healthy.

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Practical Tips

If you want to spend your money on this supplement because you like the taste and it’s convenient, great. And like I said, it’s a healthy product; it’s just not special.

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But if you don’t want to spend you hard-earned money on a product that’s more than twice as expensive per kilo as smoked salmon, here are some practical suggestions:

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1. Make your own muesli, or yoghurt topper, or snack mix:

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It literally doesn’t matter what you shove in there. There’s no magic to it, just go with the nuts, seeds, dried fruit you like and that work within your budget:

• Nuts: walnuts, pecans (my fave), sliced almonds, hazelnuts.

• Seeds: flaxseed, linseed, chia seeds, sunflower seeds.

• Dried fruit: raisins, sultanas, dates (personal fave), dried prunes.

• Fresh fruit (add as you serve): grated apple, banana, berries.

• A spice if you want (probably doesn’t do much but why not?): cinnamon, ginger, nutmeg, cardamom.

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2. Add random plant foods to any meal you can:

• Olives on everything!

• Capers (personal fave) go great with potato salad.

• Fruit: I love pear or mango on a salad.

• Seeds also go great on a salad, and Sainsburys do a “salad topper” (Pumpkin Seeds, Green Peas, Sunflower Seeds) for about £11 per kilo.

• Good old fashion pickled onion with a cheese plate!

• Pickled red onion (if you want to be a posho haha) is great with BBQ foods, poke bowls, even nachos and tacos.

• Sesame seeds go well on stirfries, and in poke bowls.

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3. Add spices and herbs to stuff.

• Chilli flakes go well on nearly everything!

• Oregano, thyme, rosemary etc complement a range of stews and pastas.

• Fresh ginger and garlic on stirfries.

• Turmeric complements a range of dishes including scrambled eggs!

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4. Just eat more whole fruit and veg generally:

Getting a diversity of plant foods is a good thing.

But what a supplement like Daily30+ misses is the energy-diluting effect of whole fruit and veges in the diet.

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Many whole plant-foods have incredibly low-energy density. Meaning you can have really large portion sizes, but still eat fewer calories. This article includes a section on how adding veges to meals causes people to spontaneously consume fewer calories.

So if you’re:

• having pasta and meatballs, fill half the plate with eg courgette, aubergine, pepper.

• having chicken and noodles, fill half the plate with eg beansprouts, cabbage, broccoli.

• having a Sunday lunch, fill half the plate with eg carrots, parsnips and peas.

• having fish fingers fill half the plate with eg peas, carrots, sweetcorn etc.

You get the picture.

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Put these bad boys in the fridge and enjoy them on a hot day. Thank me later.

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Finally, snacking on fruit is great. My current obsession is keeping a tin of mandarins in juice in the fridge and eating it after a run while I cook my dinner. Bananas are a great on-the-go snack, as is a small bag of dried fruit, or a small bag of grapes or cherries.

Enjoy!

-A previous version of this post stated that the flaxseed in this product is a good source of alpha linoleic acid (ALA). Thank you to Ursula Arens and Alan Marson who contacted me to point out that the flaxseed in this product is whole flaxseed which does not deliver ALA in the way that grinding it can or - even better - flaxseed oil.

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*Some trials might compare a product or food as a “swap” for a product or food typically consumed to show it can be a useful dietary exchange. But the important thing here is 1) choosing a defined primary outcome ideally which is clinically relevant, and 2) choosing a reasonable comparison, and 3) limiting your conclusions about that product taking into account what you compared it to.